Plasma n-3 fatty acids and psychological distress in aboriginal Cree Indians (Canada).

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TitlePlasma n-3 fatty acids and psychological distress in aboriginal Cree Indians (Canada).
Publication TypeResearch
Year of Publication2009
AuthorsLucas M, Dewailly E, Blanchet C, Gingras S, Holub BJ
Keywordsenvironmental health, multi community
Abstract

OBJECTIVE: To examine the relationship between psychological distress (PD) and plasma n-3 long-chain (LC) PUFA, i.e. EPA, docosapentaenoic acid (DPAn-3) and DHA. DESIGN: Population-based, cross-sectional Santé-Québec Health Survey (1991). Participants were categorized as high-level PD if they scored over the 80th percentile of the PD Index in the Santé-Québec Survey; non-distressed subjects were those who scored less than this cut-off. Associations between tertiles of n-3 fatty acids (FA) and the risk of high-level PD were expressed as odds ratios, with the lowest tertile as the reference group. SETTING: Québec, Canada. SUBJECTS: Data were analysed from a representative sample of 852 James Bay Cree Indian adults aged 18 years and over. RESULTS: Proportions of n-3 FA were statistically significantly lower in the PD than in the non-distressed group. After adjustment for confounders, EPA was the only individual n-3 FA significantly associated with the risk of high-level PD. Combinations of EPA + DHA or EPA + DPAn-3 + DHA or the sum of n-3 were also associated with the risk of high-level PD. Compared with the lowest tertile of EPA + DHA, the OR for high-level PD was 0.89 (95 % CI 0.59, 1.36) for the second and 0.56 (95 % CI 0.32, 0.98) for the third tertile, after controlling for confounders. CONCLUSIONS: In the present retrospective, cross-sectional study, we found that proportions of n-3 LC PUFA in plasma phospholipids, markers of n-3 LC PUFA consumption from fish, were inversely associated with PD.

URLhttp://www.ncbi.nlm.nih.gov/pubmed/19243672
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