Lingonberry (Vaccinium vitis-Idaea L) Mobilizes L6 Muscle GLUT4 Transporters and Exerts Anti-Obesity and Antidiabetic Effects in vivo

Tue, 04/28/2015 - 10:25 -- Tracy Wysote
TitleLingonberry (Vaccinium vitis-Idaea L) Mobilizes L6 Muscle GLUT4 Transporters and Exerts Anti-Obesity and Antidiabetic Effects in vivo
Publication TypeResearch
Year of Publication2014
AuthorsEid HM, Brault A, Ouchfoun M, Thong F, Vallerand D, Musallam L, Arnason JT, Sweeney G, Haddad PS
KeywordsADPP, Anti Diabetic Plant Project, Diabetes Mellitus, Type 2
Abstract

Abstract

Lingonberry (Vacciniumvitis-idaea L.) is an important part of Scandinavian
diet. It is also popular in some parts of Europe and North America, and is used to
produce confectionary and food products. This plant has been identified among
species used by the Cree of EeyouIstchee (northern Quebec) to treat symptoms
of diabetes.
In a previous study, the ethanol extract of V. vitis berries enhanced glucose
uptake in C2C12 muscle cells through stimulation of AMP-activated protein
kinase (AMPK) pathway. In this study, we firstly investigated the effect of this
product on the translocation of insulin-sensitive glucose transporters GLUT4
in L6-GLUT4myc skeletal muscle cells. V. vitis extract (200 μg/ml, 18h)
significantly increased glucose uptake and induced GLUT4 translocation to the
cell membrane of L6 cells through an insulin-independent mechanism involving
AMPK.
Secondly, we carried out in vivo experiment to validate its antidiabetic
effect. The extract was administered to diabetic KKAy mice for 10 days. V. vitis
decreased glycaemia, cumulative food intake and body weight. Moreover, V.
vitis tended to increase skeletal muscle GLUT4 expression and attenuated
hepatic statuses.
These results demonstrate that V. vitis berries represent a promising avenue
for the culturally adapted management of obesity and diabetes in Canadian
aboriginals.
Keywords: Type 2 diabetes mellitus; Obesity; GLUT4; V. vitis; lingonberry;
KKAy mice; AMPK.
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